The standard lv1 mass driver has blast radius of 4 meters, a splash of 116 damage and a direct damage of 242.
It has a clip of 6 and 18 shots total. It can fire one shot a second and a reload time of 4 seconds.

There are several different kinds of proto large missiles, so we will go through all of them.
XT-201s: Direct damage is 507, splash is 104 and blast radius is 3m. Fire interval is 2.5 seconds and fires 4 shots per volly.
XT-201 Cycled: Direct damage is 456.3, spash is 93.6 and blast radius is 1.8m. fire interval is 2.5 seconds and fires 4 shots per volly.
XT-201 Fragmented: Direct damage is 418, splash is 104 and blast radius is 4m. Fire interval is 2.5 seconds and fires 4 shots per volly.
XT-201 Accelerated: Direct damage is 507. splash is 104 and blast radius is 3m. Fire interval is 2.5 seconds and fires 4 shots per volly.

As you can see the standard 1v1 mass driver has more splash radius and splash damage than the proto missile launchers mounted on tanks. A significant meter on most of them, only .4m more than fragmented but more than double the range than splash radius than the cycled.

MISSILE SPREAD

Now, the large missile turrents should have an advantage of payloads per firing interval, they should but the spread of the missiles are uneven and just as in accurate, your missiles will never travel the same flight path as lightning will never strike the same spot twice. This being said, you usally hit an infantry soldier with the splash of 1-3 missiles, never 4 but every so often 1, funny how that works. Standard mass driver only has to hit with its single round.

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Lets take the average of 2 missiles splash damage, we will use the the fragmented because it has the largest blast.
104 damage per missile. 2 missiles= 208 damage if 3 missles hit it would be 312 damage.
Keep in mind, the fire interval is 2.5 seconds, so the mass driver will have fired 2 rounds and will most likely have a third in the air before the tank fires its second volly.
2 standard mass driver rounds are 232 damage and the third would bump it to 348 damage.
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Yes there are some direct hits with both weapons, but both are seldom and are devastating
The standard mass driver can quite often out DPS proto large missles, as evident here.

Now that we know the standard mass driver dwarfs proto tank missiles, lets check out the proto mass driver... the boundless.
159.7 direct damage, 76.6 splash, blast radius of 6.6m, clip 8, reload of 4s and 25% higher fire rate than the standard MDs.
yep... 6.6m splash. more than double the splash on most large missile turrents. almost 4 times the proto cycled.
Add in the MD operation skill to even use the boundless (requires LV5, 5% blast radius per level) and the splash range is 8.25 splash radius... more than double the most anti infaintry missle, the proto fragmented, and nearly triple that of the other 2. not even gona talk about cycled... kinda depressing. throw on some damage mods and some profficentcy and it is much more potent than a tank wanting to blow stuff up